Different types of leukemia are formed from different cells. To understand the different types of leukemia, it helps to know something about the blood and lymph systems.
Most blood cells in the body develop from cells in the bone marrow — the spongy material in the center of the bones called stem cells. Stem cells mature into different kinds of blood cells, each with its own special job:
Bone marrow is found in the medullary cavities — the centres of bones. The bone marrow is where circulating blood cells are produced — a process known as haematopoiesis.
We have recently demonstrated that IgD hi B cells can occupy an extravascular perisinusoidal niche in the bone marrow in addition to the well-established follicular niche in conventional secondary lymphoid organs. The spleen has long been considered to be the site at which newly formed B lymphocytes mature into IgD hi naive recirculating B cells, but the existence of mutant mice that have selectively lost mature B cells in the bone marrow prompted an examination of B-cell maturation at this latter site.
The Immune System in Health and Disease. The greater part of lymphocyte development in mammals occurs in the specialized environments of the central lymphoid organs—the bone marrow and the liver in the fetus for B cells and the thymus for T cells.
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